Gatehouse
Working Group
 

This event is closed.

Meeting Summary: Cell types are the building blocks of organismal complexity and diversity and are themselves the product of complex dynamical processes of development (differentiation) and evolution. A previous SFI working group has proposed a novel theory of cell type origination and evolution published in Nature Reviews Genetics in 2016 (NRG 17:744-757). This follow-up working group will now develop a more operationalized application of the previously developed theoretical model. This is especially pertinent as new data from single cell sequencing allow us to trace the trajectories of cell linages with ever increasing accuracy. However, this data deluge is in dire need for a theoretical foundation grounded in the developmental and evolutionary dimensions of cells as complex systems.

Participants
Stein Aerts, VIB-KU Leuven Center for Brain and Disease Research
Detlev Arendt, European Molecular Biology Laboratory
Manfred D. Laubichler, ASU; Santa Fe Institute
Ed Lein, Allen Institute for Brain Science
Cong Liang, Tianjin University
Mihaela Pavlicev,Cincinnati Children's Hospital Medical Center
Orit Rosenblatt-Rosen, The Broad Institute
Arnau Sebé-Pedrós, Centre for Genomic Regulation (CRG)
Günter Wagner, Yale University
Sara Walker, Arizona State University

Purpose: 
Research Collaboration
SFI Host: 
Manfred Laubichler, Detlev Arendt, Günter Wagner