Collins Conference Room
Micro Working Group
Speaker: 
John Pepper (National Cancer Institute; SFI)

This event is by invitation only.

Abstract: Resource ecology typically constrains and guides evolution, and the somatic cellular evolution of cancer may be no exception to this. Several major risk factors for cancer involve vascular oversupply of energy to affected tissues. Here, we propose a mechanistic explanation for the association between energy oversupply and cancer risk, which we call the metabolic cancer suppression hypothesis: We hypothesize that oncogenesis is normally suppressed by organismal physiology that regulates and strictly limits normal energy supply to somatic cells, and that this protection is removed by abnormal oversupply of energy.

We evaluate this hypothesis using a computational model of somatic cell evolution to simulate experimental manipulation of the vascular energy supply to a tissue. The model simulates the evolutionary dynamics of somatic cells during oncogenesis.

In our simulation experiment, we found that under plausible assumptions, elevated energy supply to a tissue led to the evolution of elevated energy uptake by somatic cells, leading to the rapid evolution of both defining traits of cancer cells: hyperproliferation, and tissue invasion.

Our results support the hypothesis of metabolic cancer suppression, suggesting that vascular oversupply of energetic resources to somatic cells removes normal energetic limitations on cell proliferation, and that this accelerates cellular evolution toward cancer.

Those unable to attend can stream the lecture from Twitter and our YouTube page.
 

Purpose: 
Research Collaboration
SFI Host: 
Jennifer Dunne