Buhnerkempe, M. G.,Roberts, M. G.,Dobson, A. P.,Heesterbeek, H.,Hudson, P. J.,Lloyd-Smith, J. O.
Many disease systems exhibit complexities not captured by current theoretical and empirical work. In particular, systems with multiple host species and multiple infectious agents (i.e., multi-host, multi-agent systems) require novel methods to extend the wealth of knowledge acquired studying primarily single-host, single-agent systems. We outline eight challenges in multi-host, multi-agent systems that could substantively increase our knowledge of the drivers and broader ecosystem effects of infectious disease dynamics.