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Aging in Single-celled Organisms: from Bacteria to the Whole Tree of Life

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  • Summary

Meeting Synopsis

This working group will bring together experimentalists and theoreticians to better understand the processes and implications of how single-celled organisms age. General principles will be drawn from high-throughput growth and division data of aging single-cells. Energetics by which they store and process information will be connected with those in larger, multicellular organisms. Some key questions this working group will consider include how the aging clock in a single-celled organism is coupled to that of a more complex organism in which it resides (and vise versa), how aging changes with growth and division, how cells with different age process information differently from the environment, and how aging differ across the tree of life.  

 

This event is supported by the James S. McDonnell Foundation Grant Number 220020491, Adaptation, Aging, and the Arrow of Time. Any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the James S. McDonnell Foundation.





  • Resources
  • Diversity of ageing across the tree of life
  • Two stochastic processes shape diverse senescence patterns in a single‐cell organism
  • Mutation dynamics and fitness effects followed in single cells
  • Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
  • Aging, mortality, and the fast growth trade-off of Schizosaccharomyces pombe