Noyce Conference Room

Nathalie Balaban (The Hebrew University)

Abstract.  We describe a recent approach for distinguishing between stochastic and deterministic sources of variability, focusing on the mammalian cell cycle. Variability between cells is often attributed to stochastic noise, although it may be generated by deterministic components. Interestingly, lineage information can be used to distinguish between noise and determinism. Analysis of correlations within a lineage of the mammalian cell cycle duration revealed its deterministic nature. Here we discuss the sources of such variability and the possibility that the underlying deterministic process is due to the circadian clock. More generally, we discuss the effect of deterministic chaos on the statistics measured in lineages of cells.

Research Collaboration
SFI Host:
Michale Lachmann