SFI Working Paper Abstract
1990
| Title: | Protein Evolution of Rugged Landscapes |
| Author(s): | Catherine A. Macken and Alan S. Perelson |
| Files: | [No electronic files available.] |
| Paper #: | 90-006 |
| Abstract: | We analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation. |