Edited by Alan S. Perelson and Stuart A. Kauffman

Preface
Alan S. Perelson and Stuart A. Kauffman

Rugged Landscapes and Evolution

Optimization on Rugged Landscapes
Richard Palmer

A Spin-Glass Model of Evolution
C. Amitrano, L. Peliti, and M. Saber

What Can Physics Do For Biology?
D. L. Stein

Optimization of RNA Structure and Properties
P. Schuster

Somatic Evolution of Antibody Variable-Region Genes and Maturation of the Immune Response

Affinity Maturation: A Retrospective View
Herman N. Eisen

Maturation Through Hypermutation and Selection
C. Berek and M. Apel

Affinity Maturation on Rugged Landscapes
Catherine Macken and Alan S. Perelson

Maturation of the Humoral Immune Response: A Neo-Darwinian Process?
Tim Manser

The NK Model of Rugged Fitness Landscapes and Its Application to Maturation of the Immune Response
Stuart A. Kauffman and Edward D. Weinberger

Use of Antibodies as Molecular Mimics to Probe Intermolecular Interaction Landscapes
William V. Williams, Thomas Kieber-Emmons, David B. Weiner, and Mark I. Greene

Affinity Maturation and Learning in Immune Networks
Gerard Weisbuch and Alan S. Perelson

Auto-Anti0Idiotype and Antigen as Selective Factors Driving B-Cell Affinity Maturation in the Immune System
Gregory W. Siskind

Somatic Mutation and the Antibody Repertoire: A Computational Model of Shape Space
Richard G. Weinand

Applied Molecular Evolution

Evolution of Proteins from Random Sequences: A Model for the Protein Sequence Space and an Experimental Approach
Wlodek Mandecki

Studies in the Evolution of Biological Activity from Random Sequences
Marshall S. Z. Horwitz, Dipak K. Dube, and Lawrence A. Loeb

The Catalytic Potential of RNA
Debra L. Robertson and Gerald F. Joyce

Origin of Life Models

Dynamics of Autocatalytic Reaction Networks
P. Schuster

Index