Andy Wuensche studied architecture in London graduating in 1968, and made a career in architecture until about 1992, working on a wide variety of projects in the UK, France and East Africa.

His change towards science began in the late 80's, when he became interested in cellular automata and found ways of reconstructing their basins of attraction. In 1990 he brought this work to the attention of Stuart Kauffman, Chris Langton, and others at the Santa Fe Institute. He has been a member of SFI since that time.

His book "The Global Dynamics of Cellular Automata" was published in 1992, in SFI's Studies in the Sciences of Complexity. He later generalized his methods for Random Boolean Networks.

In 1992 he enrolled as a postgraduate student in the School of Cognitive and Computing Sciences, University of Sussex, and completed his D.Phil. in 1996. He created a software program "Discrete Dynamics Lab" (DDLab) that he continues to develop, and that is widely used in research and education. His research interests are in emergent structures in cellular automata, and in discrete dynamical networks in general, their basins of attraction, and applications to genetic regulatory networks and understanding memory.